In order to appreciate new substances which might possibly be relevant in future, the ICPR decided to implement a special monitoring programme within the Chemistry monitoring programme for the Rhine for 2013. The aim is to detect new substances in the Rhine water by applying the HPLC MS/MS analysis methods developed in Switzerland. The results of this special monitoring programme, in particular the choice of substances to be analysed present an important basis for the Rhine Chemistry monitoring programme 2015-2020.